in chinese symbolism, an elderly person holding a peach and standing on auspicious clouds with a crane, symbolizes luck, wisdom, and longevity. in this issue, xiao et al. report the transcriptional profiles of peripheral white blood cells from centenarians, centenarian-children, and their spouses and find that autophagy-lysosomal function is significantly enhanced in centenarians. decreased intracellular accumulation of waste products via enhanced autophagy (shown in the clouds at bottom) may serve as a mechanism to prolong healthy life span. 文章链接:https://genome.cshlp.org/content/28/11.cover-expansion">